Deep Dive into GLP-1 Weight Loss Drugs

Kansas City, Kan- Key points from today’s guests:

Cynthia Zabroske, used GLP-1 drug for weight loss

  • Cynthia has been dealing with the natural stages of life – getting older and gaining weight – but she wanted help with a healthier lifestyle.
  • She was at the highest weight she had ever been last year at age 60 and she was looking to make a changes.
  • Her doctor prescribed a GLP-1 medication, but it was a type she was unable to tolerate. There are many GLP-1 medications and so the doctor changed her prescription.
  • The treatment has helped her get into the right mindset and make positive changes.
  • With her weight loss success, exercise has become fun. Pickleball is now a favorite activity, along with walking and weights.
  • She definitely sees food differently and she is more selective in what she eats.

Dr. Johanna Finkel, MD, OBGYN, obesity medicine specialist, The University of Kansas Health System

  • Someone with a BMI between 27 to 29.9 with a co-morbidity – and something related to their weight such as high blood pressure, diabetes, high cholesterol, sleep apnea – qualify for these weight loss medications. Or if they have a BMI over 30.
  • I have conversations with patients on weight loss drugs about adding more protein to the diet and making good food choices.
  • There is a concern with bone density, especially with older women, so strength training and maintaining vitamin D levels are important especially when taking GLP-1 drugs.
  • Dr. Finkle recommends getting screened before beginning these types of drugs.
  • Expand your health goals based on your entire health profile – How are you feeling? Are you more active? Are you better able to run around with your grandkids?
  • Focus on the health measures you want to improve.

Dr. John Thyfault, Ph. D., director, KU Diabetes Institute; co-principal investigator, Kansas Center for Metabolism and Obesity Research

  • When you eat a meal, you produce a hormone called insulin. Insulin tells the cells in your body to take glucose out of the bloodstream and store them away or use them.
  • GLP-1 helps the pancreas make more insulin.
  • The drugs can make you more full and the digestive process slows down.
  • In a select trial with 17,000 people with cardiovascular issues, the trial found that GLP-1 drugs lowered mortality for about 10 percent of people in the study, so there could be some additional benefits.
  • This is a great tool for people who are battling with obesity.
  • We need to pay more attention to research around menopause as well.

Katy Harvey, binge eating specialist

  • With eating disorders, it is about constant chatter in the brain.
  • A binge eating disorder is a type of eating disorder where people have strong compulsions toward eating and they may experience a loss of control around food.
  • We see a lot of medical co-morbidities with binge eating – diabetes, insulin resistance, and cardiac disease.
  • These drugs are helping people in meaningful ways with their eating disorders.
  • There is some research around the use of these drugs and improvement in mental health.

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